Circulating Fetal cells (CFCs)

Isolation of circulating fetal cells (CFCs) from maternal peripheral blood has been a major goal for non-invasive prenatal diagnosis. Up until now, engineering difficulties and ineffective bioreagents and system integrations have resulted in inconsistent fetal cell capturing and purity, hampering its long-sought prenatal application and deployment in the commercial setting. Abnova Diagnostics develops and provides GMP bioreagents and system solutions for effective isolation of CFCs as early as 7 week of gestation, thereby providing access to the complete fetal nuclear genome for genetic analysis via fluorescent in situ hybridization (FISH), microarray, and next generation sequencing (NGS).

Extravillous trophoblasts (EVTs) isolation

Prenatal Detection of Fetal Trophoblasts in Maternal Circulation

  • 9 mL whole blood of pregnant donor.
  • CytoChipNano coated with HLA-G capture Mab.
  • CFC detected with TBA-TRITC and CD45-APC Mabs.
Fetal nucleated RBCs (fnRBCs) isolation

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