Immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) staining of actinin-4 (ACTN4) as adjuvant biomarker for lung adenocarcinoma.

Abnova Diagnostics provides companion class I in vitro diagnostic kits for immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) analysis of actinin- 4 (ACTN4). With the technological supports from Abnova's ISO13485 facility, we provide the best quality bioreagents including monoclonal antibodies and FISH probes that are certified by ASR (analyte specific reagent) and GMP for quality assurance.

ACTN4 is an actin binding protein which participates in cell motility, invasion growth, and cancer metastasis. Overexpression of ACTN4 protein and ACTN4 gene amplification are related to lung, ovarian, and pancreatic cancer prognosis, chemoresistance, invasion and progression from stage 1 to stage 3. ACTN4 monoclonal antibody IHC staining and FISH probe hybridization assist pathologists and clinical researchers with ACTN4 statistical significance and clinical relevance for disease and treatment management.


 ACTN4 DNA and Protein Detection in Lung Adenocarcinoma
Human lung adenocarcinoma stained with ACTN4 DNA Probe.   Human lung adenocarcinoma stained with ACTN4 monoclonal antibody.
 ACTN4 Lung Adenocarcinoma Clinical Studies
ACTN4 FISH positive cases showed significantly poorer prognosis than negative cases in Stage I lung adenocarcinoma.
Noro R et al. Ann Oncol. (2013)
In ACTN4 IHC positive group of Stage-II/IIIA patients with lung adenocarcinoma, prognosis was significantly higher in the ADJ subgroup compared with the observation subgroup.
Miura N. et al. Oncotarget (2016)

©2017 Abnova Diagnostics. All rights reserved.