Microfluidic Chip Sample Preparation Automation for Pre- and Post-Enrichment of Circulating Rare Cells.

Three major subtypes of circulating rare cells (CRCs) in clinical applications are circulating tumor cells (CTCs), circulating progenitor cells (CPCs), and circulating fetal cells (CFCs). Abnova’s CytoPrep™ is a bio-robotic automation for sample preparation of CytoChipNano™ microfluidic chip. CytoPrep™ complements the CytoQuest™ CR positive enrichment system by alleviating all CytoChipNano™ manual operations involved in capture antibody coating, and detecting antibody and mutaFISH™ probe staining both before and after enrichment of CRCs. It provides unprecedented precision, accuracy, and reproducibility required for clinical adoption.

CytoPrep™ combines two 4-axial robotic arms, sensors, and smart software to perform complex biological tasks of CytoChipNano™ sample preparation. Starting from a fresh CytoChipNano™ housed in an addressable module, the 4-axial robotic arms simulate pipetting, aspirating, transferring, washing, and staining workflow for CytoChipNano™. The versatile robotic arms are guided by a multitude of real-time electrical and mechanical sensors, and intelligent algorithm for high throughput and multi-task functions. The entire workflow is operated under a fully transparent and self-contained environment to minimize cross contamination.

CytoPrep™ meets the rigorous requirement of high volume processing by bridging sample preparation with enrichment for a seamless transition from a clinical research platform to a robust in vitro diagnostic workstation. CytoPrep™ uses the same repertoire of circulating epithelial and tumor cell kits, mutaFISH™ probes, and peripheral bioreagents as in the CytoQuest™ CR system. CytoPrep™ is a powerful, sample preparation platform in the growing field of CRCs and derived clinical applications.

CRC subtypes

  • Circulating Tumor Cells (CTCs)
  • Circulating Progenitor Cells (CPCs)
  • Circulating Fetal Cells (CFCs)

CytoPrep™ Advantages

  • Precision, Accuracy, & Reproducibility
  • High Throughput & Multi-Tasking
  • Minimize Cross Contaminations
  • Automated Sample Preparation

CytoPrep™ Integration

  • Total Solution Workstation
  • Two 4-Axial Robotic Arms
  • In-Process Controls and Sensors
  • Intelligent Software Algorithm
  • Addressable Chip Modules
  • Fully Transparent Operation
  • Self-Contained Environment


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